Resources and Studies

Below is a list of studies using regenerative medicine for treating orthopedic ailments

 

Osteoarthritic Joint Pain

Joint Injection

Kon E, et al. (2010) Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions.
http://www.ncbi.nlm.nih.gov/pubmed/19838676

Khoshbin  A, et al. (2013)  The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis: a systematic review with quantitative synthesis. http://www.ncbi.nlm.nih.gov/pubmed/24286802

Sánchez M, et al. (2012) Ultrasound-guided platelet-rich plasma injections for the treatment of osteoarthritis of the hip. http://rheumatology.oxfordjournals.org/content/51/1/144.long

Centeno C, et al. (2016)  A dose response analysis of a specific bone marrow concentrate treatment protocol for knee osteoarthritis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575428/

 

In Conjunction with Surgical Treatment

Fortier LA, et al. (2010) Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in an equine model. http://www.ncbi.nlm.nih.gov/pubmed/20720135

Milano G, et al. (2010) The effect of platelet-rich plasma combined with microfractures on the treatment of chondral defects: an experimental study in a sheep model. http://www.ncbi.nlm.nih.gov/pubmed/20433936

Buda R, et al. (2015) One-step bone marrow-derived cell transplantation in talar osteochondral lesions: mid-term results. http://www.ncbi.nlm.nih.gov/pubmed/25606518

Meniscus or Ligament Injuries

Foster TE, et al. (2009) Platelet-rich plasma: from basic science to clinical application. http://www.ncbi.nlm.nih.gov/pubmed/19875361

Murray MM, et al. (2009) Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffold. http://www.ncbi.nlm.nih.gov/pubmed/17415785

Braun HJ, et al. (2013) The Use of PRP in ligament and meniscal healing. http://www.ncbi.nlm.nih.gov/pubmed/24212368

Yu H, et al. (2015) Meniscus repair using mesenchymal stem cells – a comprehensive review. http://www.ncbi.nlm.nih.gov/pubmed/25925426

Cook JL, et al. (2016) Multiple injections of leukoreduced platelet rich plasma reduce pain and functional impairment in a canine model of ACL and meniscal deficiency. http://www.ncbi.nlm.nih.gov/pubmed/26403590

Muscle and Tendon Injuries

Lateral Epicondylitis

Peerbooms JC, (2010) Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-Year follow up. http://www.ncbi.nlm.nih.gov/pubmed/20448192

Gosens T, et al. (2011) Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up. http://www.ncbi.nlm.nih.gov/pubmed/21422467

Mishra A, et al. (2014) Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients. http://www.ncbi.nlm.nih.gov/pubmed/23825183

 

Patellar Tendonitis

Cervellin M, et al. (2012) Autologous platelet-rich plasma gel to reduce donor-site morbidity after patellar tendon graft harvesting for anterior cruciate ligament reconstruction: a randomized, controlled clinical study. http://www.ncbi.nlm.nih.gov/pubmed/21678095

Di Matteo B, et al. (2015) Platelet-rich plasma: evidence for the treatment of patellar and Achilles tendinopathy—a systematic review. http://www.ncbi.nlm.nih.gov/pubmed/25323041

Pascual-Garrido C, et al. (2012) Treatment of chronic patellar tendinopathy with autologous bone marrow stem cells: a 5-year followup. http://www.ncbi.nlm.nih.gov/pubmed/22220180

 

Rotator Cuff Tears

Randelli P, et al. (2011) Platelet rich plasma in arthroscopic rotator cuff repair: a prospective RCT study, 2-year follow-up. http://www.ncbi.nlm.nih.gov/pubmed/21570659

Hernigou P, et al. (2014) Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study. http://www.ncbi.nlm.nih.gov/pubmed/24913770

 

Achilles Tendinopathy

Sanchez M, et al. (2007) Comparison of surgically repaired Achilles tendon tears using platelet rich fibrin matrices. http://www.ncbi.nlm.nih.gov/pubmed/17099241

Stein BE, et al. (2015) Outcomes of acute Achilles tendon rupture repair with bone marrow aspirate concentrate augmentation. http://www.ncbi.nlm.nih.gov/pubmed/25795246

Spine

Pettine K, et al. (2015) Percutaneous Injection of Autologous Bone Marrow Concentrate Cells Significantly Reduces Lumbar Discogenic Pain Through 12 months. http://onlinelibrary.wiley.com/doi/10.1002/stem.1845/abstract;jsessionid=4B093BB048A7B7E6ED042103925DBB2A.f03t02

Pettine K, et al. (2016) Treatment of discogenic back pain with autologous bone marrow concentrate injection with minimum two year follow-up. https://www.ncbi.nlm.nih.gov/pubmed/26156727

Yetsa A. Tuakli-Wosornu, et al. (2016) Lumbar Intradiskal Platelet-Rich Plasma (PRP) Injections: A Prospective, Double-Blind, Randomized Controlled Study. https://www.sciencedirect.com/science/article/pii/S1934148215009715

Monfett M, et al. (2016) Intradiscal platelet-rich plasma (PRP) injections for discogenic low back pain: an update. https://www.ncbi.nlm.nih.gov/pubmed/27073034

Fractures

Galasso O, et al. (2008) Expandable intramedullary nailing and platelet rich plasma to treat long bone non-unions. http://www.ncbi.nlm.nih.gov/pubmed/19384608

Bursitis

Sampson S, et al. (2008) Platelet rich plasma injection grafts for musculoskeletal injuries: a review. http://www.ncbi.nlm.nih.gov/pubmed/19468902

Additional References

Murphy M, et al. (2013) Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. http://www.ncbi.nlm.nih.gov/pubmed/24232253

Cassano JM, et al. (2016) Bone marrow concentrate and platelet-rich plasma differ in cell distribution and interleukin 1 receptor antagonist protein concentration. http://www.ncbi.nlm.nih.gov/pubmed/26831858

Wang SW, et al. (2014) Identification of α2-Macroglobulin as a Master Inhibitor of Cartilage-Degrading Factors That Attenuates the Progression of Posttraumatic Osteoarthritis. http://www.ncbi.nlm.nih.gov/pubmed/24578232

Cicha I, et al. (2004) Activated human platelets release connective tissue growth factor. http://www.ncbi.nlm.nih.gov/pubmed/15045137

De Mos M, et al. (2008) Can platelet-rich plasma enhance tendon repair? http://www.ncbi.nlm.nih.gov/pubmed/18326832

Evans, C. (1999) Cytokines and the role they play in the healing of ligaments and tendons. http://www.ncbi.nlm.nih.gov/pubmed/10492026

Kumar V, and JR Chapman. (2008) Autologous thrombin: intraoperative production from whole blood. http://www.ncbi.nlm.nih.gov/pubmed/18705544

Marx RE, et al. (1998) Platelet-rich plasma: growth factor enhancement for bone grafts. http://www.ncbi.nlm.nih.gov/pubmed/9638695

Weibrich G, et al. (2004) Effect of platelet concentration in platelet-rich plasma on the peri-implant bone regeneration. http://www.ncbi.nlm.nih.gov/pubmed/15050897

Zechner W, et al. (2003) Influence of platelet-rich plasma on osseus healing of dental implants: a histologic and histomorphometric study in minipigs. http://www.ncbi.nlm.nih.gov/pubmed/12608664

Woodell-May J, et al. (2011) Autologous protein solution inhibits MMP-13 production by IL-1β and TNFα-stimulated human articular chondrocytes. http://www.ncbi.nlm.nih.gov/pubmed/21437966

van Buul GM, et al. (2011) Platelet-rich plasma releasate inhibits inflammatory processes in osteoarthritic chondrocytes. http://www.ncbi.nlm.nih.gov/pubmed/21856929