Resources and Studies

Below is a list of studies using regenerative medicine for treating orthopedic ailments


Osteoarthritic Joint Pain

Joint Injection

Kon E, et al. (2010) Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions.

Khoshbin  A, et al. (2013)  The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis: a systematic review with quantitative synthesis.

Sánchez M, et al. (2012) Ultrasound-guided platelet-rich plasma injections for the treatment of osteoarthritis of the hip.

Centeno C, et al. (2016)  A dose response analysis of a specific bone marrow concentrate treatment protocol for knee osteoarthritis.


In Conjunction with Surgical Treatment

Fortier LA, et al. (2010) Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in an equine model.

Milano G, et al. (2010) The effect of platelet-rich plasma combined with microfractures on the treatment of chondral defects: an experimental study in a sheep model.

Buda R, et al. (2015) One-step bone marrow-derived cell transplantation in talar osteochondral lesions: mid-term results.

Meniscus or Ligament Injuries

Foster TE, et al. (2009) Platelet-rich plasma: from basic science to clinical application.

Murray MM, et al. (2009) Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffold.

Braun HJ, et al. (2013) The Use of PRP in ligament and meniscal healing.

Yu H, et al. (2015) Meniscus repair using mesenchymal stem cells – a comprehensive review.

Cook JL, et al. (2016) Multiple injections of leukoreduced platelet rich plasma reduce pain and functional impairment in a canine model of ACL and meniscal deficiency.

Muscle and Tendon Injuries

Lateral Epicondylitis

Peerbooms JC, (2010) Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-Year follow up.

Gosens T, et al. (2011) Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up.

Mishra A, et al. (2014) Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients.


Patellar Tendonitis

Cervellin M, et al. (2012) Autologous platelet-rich plasma gel to reduce donor-site morbidity after patellar tendon graft harvesting for anterior cruciate ligament reconstruction: a randomized, controlled clinical study.

Di Matteo B, et al. (2015) Platelet-rich plasma: evidence for the treatment of patellar and Achilles tendinopathy—a systematic review.

Pascual-Garrido C, et al. (2012) Treatment of chronic patellar tendinopathy with autologous bone marrow stem cells: a 5-year followup.


Rotator Cuff Tears

Randelli P, et al. (2011) Platelet rich plasma in arthroscopic rotator cuff repair: a prospective RCT study, 2-year follow-up.

Hernigou P, et al. (2014) Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study.


Achilles Tendinopathy

Sanchez M, et al. (2007) Comparison of surgically repaired Achilles tendon tears using platelet rich fibrin matrices.

Stein BE, et al. (2015) Outcomes of acute Achilles tendon rupture repair with bone marrow aspirate concentrate augmentation.


Pettine K, et al. (2015) Percutaneous Injection of Autologous Bone Marrow Concentrate Cells Significantly Reduces Lumbar Discogenic Pain Through 12 months.;jsessionid=4B093BB048A7B7E6ED042103925DBB2A.f03t02

Pettine K, et al. (2016) Treatment of discogenic back pain with autologous bone marrow concentrate injection with minimum two year follow-up.

Yetsa A. Tuakli-Wosornu, et al. (2016) Lumbar Intradiskal Platelet-Rich Plasma (PRP) Injections: A Prospective, Double-Blind, Randomized Controlled Study.

Monfett M, et al. (2016) Intradiscal platelet-rich plasma (PRP) injections for discogenic low back pain: an update.


Galasso O, et al. (2008) Expandable intramedullary nailing and platelet rich plasma to treat long bone non-unions.


Sampson S, et al. (2008) Platelet rich plasma injection grafts for musculoskeletal injuries: a review.

Additional References

Murphy M, et al. (2013) Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine.

Cassano JM, et al. (2016) Bone marrow concentrate and platelet-rich plasma differ in cell distribution and interleukin 1 receptor antagonist protein concentration.

Wang SW, et al. (2014) Identification of α2-Macroglobulin as a Master Inhibitor of Cartilage-Degrading Factors That Attenuates the Progression of Posttraumatic Osteoarthritis.

Cicha I, et al. (2004) Activated human platelets release connective tissue growth factor.

De Mos M, et al. (2008) Can platelet-rich plasma enhance tendon repair?

Evans, C. (1999) Cytokines and the role they play in the healing of ligaments and tendons.

Kumar V, and JR Chapman. (2008) Autologous thrombin: intraoperative production from whole blood.

Marx RE, et al. (1998) Platelet-rich plasma: growth factor enhancement for bone grafts.

Weibrich G, et al. (2004) Effect of platelet concentration in platelet-rich plasma on the peri-implant bone regeneration.

Zechner W, et al. (2003) Influence of platelet-rich plasma on osseus healing of dental implants: a histologic and histomorphometric study in minipigs.

Woodell-May J, et al. (2011) Autologous protein solution inhibits MMP-13 production by IL-1β and TNFα-stimulated human articular chondrocytes.

van Buul GM, et al. (2011) Platelet-rich plasma releasate inhibits inflammatory processes in osteoarthritic chondrocytes.